MS - LS3.B (B) Mutations - FINAL (WND 3/3/2014)

Module: Mutations

DCI: LS3.B (B) In addition to variations that arise from sexual reproduction, genetic information can be altered because of mutations. Though rare, mutations may result in changes to the structure and function of proteins. Some changes are beneficial, others harmful, and some neutral to the organism.

PE: MS-LS3-1 Develop and use a model to describe why structural changes to genes (mutations) located on chromosomes may affect proteins and may result in harmful, beneficial, or neutral effects to the structure and function of the organism

[Clarification Statement: Emphasis is on conceptual understanding that changes in genetic material may result in making different proteins.] [Assessment Boundary: Assessment does not include specific changes at the molecular level, mechanisms for protein synthesis, or specific types of mutations.]

The ideas are: 

- variations can arise from sexual reproduction, but genetic information can also be altered as a result of a mutation. 

- mutations may result in changes to the structure of proteins 

- some changes are beneficial, others harmful, and some neutral to the organism 

Possible Question Starters: 

In humans, the protein CFTR regulates the components of sweat, digestive fluids, and mucus. Which of the following would provide evidence that a genetic mutation of the CFTR protein could be harmful to humans?